Publications
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第四型介白素調控代謝恆定的功效 Anti-inflammatory Cytokine Interleukin-4 and Metabolic Homeostasiss 張懿欣 Yih-Hsin Chang 生檢雜誌2024;36:152-161 【Abstract】 【摘要】看PDF需登入會員 |
| 中文摘要 第二型糖尿病(type 2 diabetes mellitus, T2DM)是常見的內分泌疾病，其致病機轉仍然未知。遺傳和環境是最受矚目的風險因子，許多研究已證實T2DM 患者循環中有較高的發炎細胞激素，因此T2DM 發病與慢性發炎反應有密切相關性。本綜論文章結構為先介紹新陳代謝恆定(metabolic homeostasis)和發炎反應的相關性，之後討論本實驗室長期投入新陳代謝研究累積多年的發現與成果。首先以探討國人T2DM 患者細胞激素基因型與代謝參數相關性揭開序幕，所獲數據除提供發展精準醫療與疾病防治的參考資訊外，亦據以聚焦於抗發炎細胞激素第四型介白素(interleukin-4, IL-4)在新陳代謝角色的後續研究。本實驗室利用細胞與動物實驗模式，循序漸進分析並闡釋IL-4 對多種標的細胞與器官新陳代謝作用的調節活性：(1)體重管理之整體能量代謝功效；(2)中樞神經系統下視丘食慾控制機轉；(3)提升胰臟蘭氏小島 β 細胞( β cells of the pancreatic islets of Langerhans)分泌胰島素活性與保護機制；(4)提高肝臟、肌肉與脂肪等主要周邊代謝器官之代謝效率；以及(5)提升巨噬細胞的膽固醇排出活性，預防動脈粥狀硬化。簡而言之，本實驗室研究數據不但揭示IL-4 對新陳代謝作用與主要代謝器官之新穎調節功能，亦闡述透過免疫調控分子、神經內分泌系統與主要代謝器官構成的精密網絡，調控並維持代謝恆定的分子機制。 |
| 關鍵詞：第四型介白素; 新陳代謝; 肥胖; 糖尿病 |
| Abstract The etiology of type 2 diabetes mellitus (T2DM) remains not totally understood. Host genetic and environmental factors are the foci among various risks leading to diabetic onset. Abundant evidence proves that affected individuals have higher levels of circulatory acute response proteins and cytokines. Therefore, T2DM is closely correlated with chronic inflammation. The focus of this review article is to address the findings of our serial studies disclosing and documenting novel functions of anti-inflammatory cytokine interleukin-4 (IL-4) in modulating energy metabolism and metabolic imbalance. The background information concerning metabolic homeostasis and inflammation is first introduced, followed by addressing our findings concerning the association of cytokine genotypes and metabolic parameters in local T2DM population for clinical settings. Subsequently, multiple beneficial effects of IL-4 in boosting metabolic efficacy are elucidated from the perspective of its capacity in modulating: (1) overall energy metabolism; (2) hypothalamic appetite control; (3) insulin-secreting β-cells of the pancreatic islets of Langerhans; (4) major peripheral metabolic organs; and (5) the cholesterol efflux activity of macrophages. In summary, our findings not only uncovered and characterized novel activities and corresponding mechanism of IL-4 in energy metabolism but also documented integrative crosstalk among immune responses, neuroendocrine circuits and insulin-targeted organs that control and maintain metabolic homeostasis through delicate tuning insulin signaling and appetite control. |
| Key words：interleukin-4; metabolism; obesity; diabetes mellitus |
